1 Transcriptional Regulation
1
3 Activators-bind enhancer elements
Transcriptional Control—by Transcription Factors (DNA-binding proteins) Activators-bind enhancer elements Repressors-bind repressor elements (or ‘operator elements’, or ‘operators’ in bacteria) 3
4 Prokaryotic ‘Operons’
examples 4
5 Trp Operon-Biosynthesis
-10 -35 5
8 Lac Operon-Catabolism
8
10 Lactose ON -35 -10 10
11 Lactose ON -35 -10 -10 -35 11
13 In the absence of glucose….
cAMP 13
18 Combinatorial Control of Gene Expression
18
22 induced Pluripotent Stem cell
21
24 Regulatory protein 1 Off