Each Holy Cross student’s curriculum consists of common requirements (which can be fulfilled by selecting from a wide range of courses), a major, and freely elected courses. In designing their course of study, many students opt to combine majors and/or add a minor or a concentration.

| Academic Programs | Major | Minor | Concentration | Career Program |
|---|---|---|---|---|
| Accounting | ![]() | |||
| Africana Studies | SD | ![]() | ||
| Anthropology | ![]() | ![]() | ||
| Architectural Studies* | SD | SD | ||
| Art History | ![]() | ![]() | ||
| Asian Studies | ![]() | ![]() | ||
| Biology | ![]() | |||
| Catholic Studies* | SD | SD | ||
| Chemistry | ![]() | |||
| Chinese Studies | ![]() | ![]() | ||
| Chinese Language and Civilization* | SD | SD | ||
| Classics | ![]() | |||
| Computer Science | ![]() | ![]() | ||
| Deaf Studies and Sign Languages* | SD | ![]() | ||
| Economics | ![]() | |||
| English | ![]() | |||
| Environmental Studies | ![]() | ![]() | ||
| Film Studies* | SD | SD | ||
| French and Francophone Studies | ![]() | ![]() | ||
| Gender, Sexuality, and Women's Studies | SD | ![]() | ||
| German Studies | ![]() | ![]() | ||
| Health Studies | SD | |||
| History | ![]() | |||
| International Studies | ![]() | No | ||
| Italian Studies | ![]() | ![]() | ||
| Latin American and Latino Studies | SD | ![]() | ||
| Mathematics | ![]() | |||
| Medieval and Renaissance Studies* | SD | SD | ||
| Middle Eastern Studies* | SD | SD | ||
| Neuroscience | ![]() | ![]() | ||
| Music | ![]() | |||
| Philosophy | ![]() | ![]() | ||
| Physics | ![]() | ![]() | ||
| Political Science | ![]() | |||
| Psychology | ![]() | |||
| Religious Studies | ![]() | ![]() | ||
| Russian Studies | ![]() | ![]() | ||
| Russian and Eastern European Studies* | SD | SD | ||
| Sociology | ![]() | |||
| Sociology and Anthropology | ![]() | ![]() | ||
| Spanish | ![]() | |||
| Studies in World Literatures | ![]() | |||
| Studio Art | ![]() | ![]() | ||
| Theatre | ![]() | |||
| World Languages, Literatures, and Cultures | SD | ![]() |
* Student Designed Program